Units & Services / Reproductive Endocrinology, Infertility & IVF Unit
Reproductive Endocrinology, Infertility & IVF Unit
Thuriah Medical Center provides the full range of the latest
technologies of assisted reproduction for the management of infertility.
Ovulation Induction By means of drugs that stimulate the
ovaries to produce and ovulate eggs which could then be fertilized
through natural intercourse leading to conception. The drugs could take
the form of tablets or injections and will be decided on by the treating
consultant. The response is usually followed by ultrasound scanning and
sometimes hormone tests. Intrauterine Insemination (IUI) This
involves the preparation of a semen sample of the husband and injection
of the prepared sample into the uterine cavity of the wife using a very
thin tube at around the time of ovulation. This can be carried out with
or without stimulation of the ovaries. The procedure is simple and is
not painful. In Vitro-Fertilization (IVF) IVF is the
process of external fertilization in the laboratory; eggs are retrieved
from the wife at maturity, and are mixed with a prepared sample of the
husbands sperm in the IVF laboratory. They are then left in culture
media in an incubator over night to fertilize. The fertilized eggs are
then allowed to cleave to create embryos. After they develop into
embryos the best, usually 2, are selected and returned into the uterus
of the wife. The process usually involves stimulation of the ovaries by
means of medications (injections) to allow the retrieval of multiple
eggs rather than the one naturally ovulated egg as this improves the
chances of success. IVF Related Techniques Intra-cytoplasmic Sperm Injection (ICSI) The
process of micro insemination (ICSI) is similar to IVF with the only
difference in that a single sperm is injected directly an egg using a
special type of microscope (Micromanipulator). The introduction of this
technique back in 1992 marked a breakthrough in the management of male
problems and ever since has allowed many couples whose treatment would
have been hopeless to father their own genetic children. In Vitro Maturation (IVM) With
this technique immature eggs are retrieved from the ovaries following
either no or minimal stimulation and the eggs are then matured in the
IVF laboratory. Once mature the eggs are fertilized using husbands
sperm and returned to the uterus, again after cleavage and creation of
embryos. This technique is useful in special circumstances e.g. for
women with polycystic ovarian syndrome who, when stimulated, are prone
to develop unpleasant symptoms of a condition called hyperstimulation
syndrome. Assisted Hatching This method aims to increase
the chance of implantation of the replaced embryos and accordingly
improve the chance of a pregnancy as a result of IVF treatment. It
involves making a tiny hole in the wall of the embryo to help the embryo
hatch prior to implanting into the uterine wall. It could be done
mechanically, chemically or by using laser technology. The technique of
assisted hatching could benefit selected patients and doctors will
discuss this and advise when appropriate. Extended Embryo Culture & Blastocyst Transfer The
success of IVF increases with the transfer of better quality healthy
embryos. Extended embryo culture in the IVF laboratory and the delay of
the transfer of one or two embryos to five days from egg collection
helps the selection of better quality embryos and significantly improves
the chances of conception. For this treatment option however a good
number of embryos, at least five, is required. Again doctors will
discuss this and advise when appropriate. Pre-Implantation Genetic Diagnosis (PGD) The
most common reason for IVF failure is chromosomal abnormalities in the
embryos. Around 70% of embryos are usually lost before birth for this
single reason. The technology of Pre-implantation Genetic Diagnosis
offers genetic testing of an embryo prior to implantation. It is used in
conjunction with IVF and allows only those embryos diagnosed as being
free of a specific genetic disorder to be transferred into a woman to
try to achieve a pregnancy and the birth of a healthy baby.